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ZLD1039 

Cat. No. M28933

All AbMole products are for research use only, cannot be used for human consumption.

ZLD1039  Structure

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Quality Control & Documentation
Biological Activity

ZLD1039 is a potent, highly selective, and orally bioavailable EZH2 inhibitor. ZLD1039 shows potent and concentration-dependent inhibition of PRC2 enzymatic activity against EZH2 wild-type as well as Y641F, and A677G mutant enzymes with IC50 values of 5.6, 15, and 4.0 nM, respectively. ZLD1039 inhibits breast tumor growth and metastasis.

Chemical Information
Molecular Weight 612.8
Formula C36H48N6O3
CAS Number 1826865-46-6
Form Solid
Solubility (25°C) DMSO 9.09 mg/mL (ultrasonic and adjust pH to 3 with 1M HCl)
Storage 4°C, protect from light
References

[1] Xuejiao Song, et al. Sci Rep. Corrigendum: Selective inhibition of EZH2 by ZLD1039 blocks H3K27methylation and leads to potent anti-tumor activity in breast cancer

[2] Yongxia Zhu, et al. Biochem Pharmacol. Pharmacological inhibition of EZH2 by ZLD1039 suppresses tumor growth and pulmonary metastasis in melanoma cells in vitro and in vivo

[3] Li Wen, et al. Acta Pharmacol Sin. Selective EZH2 inhibitor zld1039 alleviates inflammation in cisplatin-induced acute kidney injury partially by enhancing RKIP and suppressing NF-κB p65 pathway

[4] Xuejiao Song, et al. Sci Rep. Selective inhibition of EZH2 by ZLD1039 blocks H3K27 methylation and leads to potent anti-tumor activity in breast cancer

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Abmole Inhibitor Catalog




Keywords: ZLD1039  supplier, Histone Methyltransferase, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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