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ZL0420

Cat. No. M10908

All AbMole products are for research use only, cannot be used for human consumption.

ZL0420  Structure

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Quality Control & Documentation
Biological Activity

ZL0420 is a potent and selective BET bromine domain 4 (BRD4) inhibitor of BRD4 BD1 and BRD4 BD2 IC50 27 nM and 32 nM, respectively.

Chemical Information
Molecular Weight 296.32
Formula C16H16N4O2
CAS Number 2230496-80-5
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Xi Lu, et al. Ecotoxicol Environ Saf. Novel insights into the role of BRD4 in fine particulate matter induced airway hyperresponsiveness

[2] Bing Tian, et al. Am J Respir Cell Mol Biol. Efficacy of Novel Highly Specific Bromodomain-Containing Protein 4 Inhibitors in Innate Inflammation-Driven Airway Remodeling

[3] Zhiqing Liu, et al. Eur J Med Chem. Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation

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FHT-1015 

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  Catalog
Abmole Inhibitor Catalog




Keywords: ZL0420 supplier, Epigenetic Reader Domain, inhibitors, activators

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