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Zalutumumab is a high affinity, completely human IgG1 monoclonal antibody targeting EGFR. Zalutumumab binds to domain III of the EGF receptor and acts by blocking the binding of EGF and by sterically interfering with the active conformation of the receptor. Zalutumumab binds with IgG and its Fab fragment with EC50s of 7 and 19 nM, respectively. Zalutumumab can be used for the research of cancer.
| CAS Number | 667901-13-5 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
[2] Ulrike Schick, et al. Expert Opin Biol Ther. Zalutumumab in head and neck cancer
[3] Fernando Rivera, et al. Expert Opin Biol Ther. Current situation of zalutumumab
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