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YK-029A

Cat. No. M42078

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YK-029A Structure

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Quality Control & Documentation
Biological Activity

YK-029A is an orally active inhibitor of mutant EGFR, targeting to both the T790M mutations (EGFRT790M) and exon 20 insertion of EGFR (EGFRex20ins).

Chemical Information
Molecular Weight 500.6
Formula C27H32N8O2
CAS Number 2064269-82-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jianchun Duan et al. J Thorac Oncol. Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of YK-029A in Treatment-Naive Patients With Advanced NSCLC Harboring EGFR Exon 20 Insertion Mutations: A Phase 1 Trial

[2] Bin Liu et al. Eur J Med Chem. Discovery of YK-029A, a novel mutant EGFR inhibitor targeting both T790 M and exon 20 insertion mutations, as a treatment for NSCLC

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  Catalog
Abmole Inhibitor Catalog




Keywords: YK-029A supplier, EGFR/HER2, inhibitors, activators

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