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Cat. No. M11240

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XL092  Structure

JUN04542; Zanzalintinib

Size Price Availability Quantity
5mg USD 150  USD150 In stock
10mg USD 250  USD250 In stock
25mg USD 500  USD500 In stock
50mg USD 800  USD800 In stock
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Quality Control & Documentation
Biological Activity

XL092 is an orally active, ATP-competitive inhibitor of multireceptor tyrosine kinases (RTKs), including MET, VEGFR2, AXL and MER, with IC50 values of 15 nM, 1.6 nM, 3.4 nM and 7.2 nM in cell analysis, respectively. XL092 has antitumor activity.

Chemical Information
Molecular Weight 528.53
Formula C29H25FN4O5
CAS Number 2367004-54-2
Form Solid
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage 4°C, protect from light, dry, sealed

[1] Lin Yuan, et al. J Pharm Biomed Anal. Identification of the metabolites of XL092 in rat and human by using ultra-high performance liquid chromatography high resolution mass spectrometry

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DS-1205b free base 

DS-1205b free base is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205b free base also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205b free base can inhibit cell migration in vitro and tumor growth in vivo.

Ningetinib Tosylate

Ningetinib Tosylate is a potent, orally bioavailable small molecule tyrosine kinase inhibitor (TKI) with IC50s of 6.7, 1.9 and <1.0 nM for c-Met, VEGFR2 and Axl, respectively.

Abmole Inhibitor Catalog

Keywords: XL092 , JUN04542; Zanzalintinib supplier, TAM Receptor, inhibitors, activators

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