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WYRGRL

Cat. No. M21620
WYRGRL Structure
Size Price Availability Quantity
5mg USD 240  USD240 In stock
10mg USD 400  USD400 In stock
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Quality Control & Documentation
Biological Activity

WYRGRL is a collagen type II-binding peptide. The WYRGRL peptide has an inherent affinity for the cartilage matrix component of collagen II protein.

Sequence: Trp-Tyr-Arg-Gly-Arg-Leu

Chemical Information
Solubility (25°C) Water 1 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ting Lin, et al. Carbohydr Polym . Carboxymethyl chitosan-assisted MnOx nanoparticles: Synthesis, characterization, detection and cartilage repair in early osteoarthritis

[2] Ting Lin, et al. Carbohydr Polym. Carboxymethyl chitosan-assisted MnOx nanoparticles: Synthesis, characterization, detection and cartilage repair in early osteoarthritis

[3] En Ren, et al. Adv Healthc Mater . Harnessing Bifunctional Ferritin with Kartogenin Loading for Mesenchymal Stem Cell Capture and Enhancing Chondrogenesis in Cartilage Regeneration

[4] En Ren, et al. Adv Healthc Mater. Harnessing Bifunctional Ferritin with Kartogenin Loading for Mesenchymal Stem Cell Capture and Enhancing Chondrogenesis in Cartilage Regeneration

[5] Song Xue, et al. Bioact Mater . Cartilage-targeting peptide-modified dual-drug delivery nanoplatform with NIR laser response for osteoarthritis therapy

[6] Song Xue, et al. Bioact Mater. Cartilage-targeting peptide-modified dual-drug delivery nanoplatform with NIR laser response for osteoarthritis therapy

[7] Florian A Formica, et al. J Control Release . Cartilage-targeting dexamethasone prodrugs increase the efficacy of dexamethasone

[8] Florian A Formica, et al. J Control Release. Cartilage-targeting dexamethasone prodrugs increase the efficacy of dexamethasone

[9] Tao Jiang, et al. J Nanosci Nanotechnol. Development of Targeted Nanoscale Drug Delivery System for Osteoarthritic Cartilage Tissue

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