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VTP-27999 is a highly potent and selective renin inhibitor (IC50 = 0.47 nM). VTP-27999 displays >1000-fold selectivity over related and unrelated off-targets. VTP-27999 blocks renin-stimulated ERK1/2 phosphorylation in vascular smooth muscle cells. VTP-27999 exhibits a different mode of action to aliskiren.
| Molecular Weight | 525.08 |
| Formula | C26H41ClN4O5 |
| CAS Number | 942142-51-0 |
| Solubility (25°C) | DMSO 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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