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Vitamin D2

Cat. No. M6056
Vitamin D2 Structure
Synonym:

Ergocalciferol

Size Price Availability Quantity
100mg USD 80  USD80 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Vitamin D2 is a selective inhibitor of mammalian DNA polymerase A (pol A) with IC50 of 123 mM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 396.65
Formula C28H44O
CAS Number 50-14-6
Purity >98%
Solubility 80 mg/mL in Ethanol
Storage at -20°C
References

[1] Suenaga M, et al. Curr Alzheimer Res. Different effect of vitamin D2 and vitamin D3 on amyloid-β40 aggregation in vitro.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Vitamin D2, Ergocalciferol supplier, DNA Methyltransferase, inhibitors

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