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VIT-2763 

Cat. No. M29214

All AbMole products are for research use only, cannot be used for human consumption.

VIT-2763  Structure
Size Price Availability Quantity
5mg USD 350  USD350 In stock
10mg USD 540  USD540 In stock
50mg USD 1500  USD1500 In stock
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Biological Activity

VIT-2763, an oral ferroportin inhibitor, inhibits hepcidin binding to ferroportin and blocks iron efflux. VIT-2763 has the potential in the treatment of β-thalassemia.

Chemical Information
Molecular Weight 408.43
Formula C21H21FN6O2
CAS Number 2095668-10-1
Form Solid
Solubility (25°C) DMSO 125 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Arielle L Langer, et al. Hematology Am Soc Hematol Educ Program. β-Thalassemia: evolving treatment options beyond transfusion and iron chelation

[2] Alexandros Makis, et al. Biology (Basel). Novel Therapeutic Advances in β-Thalassemia

[3] Naja Nyffenegger, et al. Int J Mol Sci. The Oral Ferroportin Inhibitor VIT-2763 Improves Erythropoiesis without Interfering with Iron Chelation Therapy in a Mouse Model of β-Thalassemia

[4] Frank Richard, et al. Am J Hematol. Oral ferroportin inhibitor VIT-2763: First-in-human, phase 1 study in healthy volunteers

  Catalog
Abmole Inhibitor Catalog




Keywords: VIT-2763  supplier, Ferroportin, inhibitors, activators

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