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Vazegepant hydrochloride

Cat. No. M10372

All AbMole products are for research use only, cannot be used for human consumption.

Vazegepant hydrochloride Structure
Synonym:

Zavegepant, BHV-3500 hydrochloride

Size Price Availability Quantity
2mg USD 136 In stock
5mg USD 224 In stock
10mg USD 320 In stock
25mg USD 592 In stock
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Quality Control & Documentation
Biological Activity

Vazegepant (BHV-3500) hydrochloride is a first-in-class, high affinity CGRP receptor antagonist (hCGRP Ki= 0.023 nM). Vazegepant hydrochloride may be useful in the effective treatment of lung inflammation associated with COVID-19.

Chemical Information
Molecular Weight 675.26
Formula C36H47ClN8O3
CAS Number 1414976-20-7
Solubility (25°C) Water 50 mg/mL
DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] David Moreno-Ajona, et al. Curr Opin Neurol. Gepants, calcitonin-gene-related peptide receptor antagonists: what could be their role in migraine treatment?

[2] Gene M Dubowchik, et al. J Med Chem. Blocking the CGRP Pathway for Acute and Preventive Treatment of Migraine: The Evolution of Success

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BAR501 is a potent and selective agonist of GPBAR1 with an EC50 of 1 μM.

Olcegepant (BIBN-4096)

Olcegepant (BIBN-4096) is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide (CGRP) receptor with IC50 of 0.03 nM and Ki of 14.4 pM for human CGRP.

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Atogepant (MK-8031) is an orally active and selective calcitonin gene–related peptide receptor (CGRP) antagonist. Atogepant can be used for the research of migraine.

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Keywords: Vazegepant hydrochloride, Zavegepant, BHV-3500 hydrochloride supplier, CGRP Receptor, inhibitors, activators

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