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Vancomycin

Cat. No. M9334
Vancomycin Structure
Size Price Availability Quantity
25mg USD 45  USD45 In stock
50mg USD 70  USD70 In stock
100mg USD 110  USD110 In stock
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Quality Control & Documentation
Biological Activity

Vancomycin is a glycopeptide antibiotic as well as a macrocyclic compound that can be used to construct models of bronchiectasis combined with lung infections, as well as for studies related to various bacterial infectious conditions.

Product Citations
Chemical Information
Molecular Weight 1449.25
Formula C66H75Cl2N9O24
CAS Number 1404-90-6
Solubility (25°C) DMSO ≥ 15 mg/mL
Storage 2-8°C, dry, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Risheng Zhao, et al. Gastroenterology. Aspirin Reduces Colorectal Tumor Development in Mice and Gut Microbes Reduce its Bioavailability and Chemopreventive Effects

[2] Alaina N Burns, et al. A Moving Target-Vancomycin Therapeutic Monitoring

[3] Eric Mhlberg, et al. Renaissance of vancomycin: approaches for breaking antibiotic resistance in multidrug-resistant bacteria

[4] Donald P Levine. Vancomycin: a history

[5] Michael J Rybak. The pharmacokinetic and pharmacodynamic properties of vancomycin

[6] M P Wilhelm. Vancomycin

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