Vancomycin is a glycopeptide antibiotic as well as a macrocyclic compound that can be used to construct models of bronchiectasis combined with lung infections, as well as for studies related to various bacterial infectious conditions.
ACS Nano. 2023 Mar 30.
Bioinspired Mild Photothermal Effect-Reinforced Multifunctional Fiber Scaffolds Promote Bone Regeneration
Vancomycin purchased from AbMole
| Molecular Weight | 1449.25 |
| Formula | C66H75Cl2N9O24 |
| CAS Number | 1404-90-6 |
| Solubility (25°C) | DMSO ≥ 15 mg/mL |
| Storage | 2-8°C, dry, protect from light, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Alaina N Burns, et al. A Moving Target-Vancomycin Therapeutic Monitoring
[3] Donald P Levine. Vancomycin: a history
[4] Michael J Rybak. The pharmacokinetic and pharmacodynamic properties of vancomycin
| Related Animal Modeling Products |
|---|
| N-Butyl-N-(4-hydroxybutyl)nitrosamine
N-Butyl-N-(4-hydroxybutyl)nitrosamine can be used to construct animal models of bladder cancer (BLCA). |
| Boromycin
Boromycin is a compound isolated from Streptomyces antibioticus and a boron-containing macrolide antibiotic with potent activity against a number of viruses, gram-positive bacteria and protozoan parasites. It can be used to induce a mouse model of pulmonary fibrosis and can be used in malaria-related studies. |
| Dextrose iron
Dextrose iron can be used to construct animal models of iron overload. |
| Prednisone acetate
Prednisone acetate is the acetate form of Prednisone and a glucocorticoid receptor agonist with anti-inflammatory and immunomodulatory properties. It can be used to construct animal models of Kawasaki disease. |
| Carrageenan
Carrageenan is a biochemical reagent that can be used to construct animal models of chronic non-bacterial prostatitis, models of synovitis, and models of prostatitis. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
