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Vactosertib Hydrochloride (EW-7197 Hydrochloride) is a potent, orally active and ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor with an IC50 of 12.9 nM. Vactosertib Hydrochloride also inhibits ALK2 and ALK4 (IC50 of 17.3 nM) at nanomolar concentrations. Vactosertib Hydrochloride has potently antimetastatic activity and anticancer effect.
| Molecular Weight | 435.88 |
| CAS Number | 1352610-25-3 |
| Solubility (25°C) | Water 50 mg/mL DMSO 50 mg/mL |
| Storage | -20°C, sealed |
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