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Vactosertib Hydrochloride

Cat. No. M14944
Vactosertib Hydrochloride Structure
Synonym:

EW-7197 Hydrochloride; TEW-7197 Hydrochloride

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Biological Activity

Vactosertib Hydrochloride (EW-7197 Hydrochloride) is a potent, orally active and ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor with an IC50 of 12.9 nM. Vactosertib Hydrochloride also inhibits ALK2 and ALK4 (IC50 of 17.3 nM) at nanomolar concentrations. Vactosertib Hydrochloride has potently antimetastatic activity and anticancer effect.

Chemical Information
Molecular Weight 435.88
CAS Number 1352610-25-3
Solubility (25°C) Water 50 mg/mL
DMSO 50 mg/mL
Storage -20°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: Vactosertib Hydrochloride, EW-7197 Hydrochloride; TEW-7197 Hydrochloride supplier, TGF-β Receptor, inhibitors, activators


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