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V-9302 is a competitive antagonist of transmembrane glutamine flux. V-9302 selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) not ASCT1. V-9302 inhibits ASCT2-mediated glutamine uptake (IC50=9.6 µM) in HEK-293 cells.
V-9302 (75 mg/kg; i.p.; daily fo 21 days) prevents tumor growth in both HCT-116 and HT29 xenograft models.
| Molecular Weight | 538.68 |
| Formula | C34H38N2O4 |
| CAS Number | 1855871-76-9 |
| Solubility (25°C) | DMSO 20 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage | -20°C, dry, sealed |
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