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UT-34 is a potent, selective and orally active second-generation pan-androgen receptor (AR) antagonist and degrader with IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild-type, F876L and W741L AR, respectively. UT-34 binds to ligand-binding domain (LBD) and function-1 (AF-1) domains and requires ubiquitin proteasome pathway to degrade the AR. UT-34 has anti-prostate cancer efficacy.
| Molecular Weight | 356.27 |
| Formula | C15H12F4N4O2 |
| CAS Number | 2168525-92-4 |
| Form | Solid |
| Solubility (25°C) | DMSO 250 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Louise Stone. Nat Rev Urol. UT-34: a promising new AR degrader
[4] Suzanne J Snodgrass, et al. J Athl Train. Shoulder Taping and Neuromuscular Control
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