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Urelumab

Cat. No. M25295

All AbMole products are for research use only, cannot be used for human consumption.

Urelumab Structure
Size Price Availability Quantity
100ug USD 220  USD220 In stock
1mg USD 560  USD560 In stock
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Quality Control & Documentation
Biological Activity

Urelumab, a fully human, non-ligand binding, CD137 agonist IgG4 monoclonal antibody, enhances T-cell and natural killer-cell antitumor activity, and may enhance cytotoxic activity of Rituximab. Urelumab can be used for the research of diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and other types of non-Hodgkin lymphoma (NHL).

Chemical Information
CAS Number 934823-49-1
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Carmen Reitinger, et al. Front Immunol. Modulation of urelumab glycosylation separates immune stimulatory activity from organ toxicity

[2] Kenji Hashimoto. Cancers (Basel). CD137 as an Attractive T Cell Co-Stimulatory Target in the TNFRSF for Immuno-Oncology Drυg Development

[3] John Timmerman, et al. Am J Hematol. Urelumab alone or in combination with rituximab in patients with relapsed or refractory B-cell lymphoma

[4] Cariad Chester, et al. Blood. Immunotherapy targeting 4-1BB: mechanistic rationale, clinical results, and future strategies

[5] Neil H Segal, et al. Clin Cancer Res. Results from an Integrated Safety Analysis of Urelumab, an Agonist Anti-CD137 Monoclonal Antibody

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Keywords: Urelumab supplier, inhibitors, activators

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