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Tyrphostin AG 1296 is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR.
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Source | Oncol Lett (2015). Figure 2. Tyrphostin AG 1296 |
| Method | cell invasion assay | |
| Cell Lines | U87MG cells | |
| Concentrations | 12.5, 50 or 200 nM | |
| Incubation Time | 8 h | |
| Results | Statistical analysis demonstrated that the anti.migration effect of tyrphostin AG 1296 in U87MG cells, increased in a dose.dependent manner |
| Cell Experiment | |
|---|---|
| Cell lines | Swiss 3T3 |
| Preparation method | Seeding cells in 24-well plates (5000 cells/well) in DMEM/10% FCS. A day later, the medium is changed to DMEM/2% FcS with or without growth factors and tyrphostins are added as indicated. Three days later count the cells in a hemocytometer |
| Concentrations | ~50 μM |
| Incubation time | 3 days |
| Animal Experiment | |
|---|---|
| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| Molecular Weight | 266.29 |
| Formula | C16H14N2O2 |
| CAS Number | 146535-11-7 |
| Solubility (25°C) | DMSO 6 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Hongwei Li, et al. Tyrphostin AG 1296 induces glioblastoma cell apoptosis in vitro and in vivo
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