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Tyrosine kinase-IN-6

Cat. No. M43486
Tyrosine kinase-IN-6 Structure
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Biological Activity

Tyrosine kinase-IN-6 is a potent and promising RON splice variants inhibitor with anti-cancer and o?antineoplastic effects.

Chemical Information
Molecular Weight 695.73
Formula C37H31F2N5O5S
CAS Number 2377507-01-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] C Houée-Lévin et al. Free Radic Res. Exploring oxidative modifications of tyrosine: an update on mechanisms of formation, advances in analysis and biological consequences

[2] Adrian Hase et al. Pharmacol Biochem Behav. Behavioral and cognitive effects of tyrosine intake in healthy human adults

[3] Justin Liu et al. Am J Respir Cell Mol Biol. Tyrosine sulfation is prevalent in human chemokine receptors important in lung disease

[4] Gonzalo Peluffo et al. Cardiovasc Res. Biochemistry of protein tyrosine nitration in cardiovascular pathology

[5] M B Calalb et al. Mol Cell Biol. Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases

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Keywords: Tyrosine kinase-IN-6 supplier, c-Met, inhibitors, activators

 
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