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TRV-130

Cat. No. M21363

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TRV-130 Structure
Synonym:

Oliceridine;Olinvo;TRV 130;TRV130

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Biological Activity

TRV 130 is a novel μ-opioid receptor (MOR) G protein-biased ligand; elicits robust G protein signaling(pEC50=8.1), with potency and efficacy similar to morphine, but with far less β-arrestin recruitment and receptor internalization.

Chemical Information
Molecular Weight 386.55
Formula C22H30N2O2S
CAS Number 1401028-24-7
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ferenc Zdor, et al. Front Mol Biosci. Recent Molecular Insights into Agonist-specific Binding to the Mu-Opioid Receptor

[2] Anthony Markham. Drugs. Oliceridine: First Approval

[3] Alan David Kaye, et al. Curr Pain Headache Rep. Novel Pharmacological Nonopioid Therapies in Chronic Pain

[4] Sebastian Schneider, et al. Biochemistry. How Oliceridine (TRV-130) Binds and Stabilizes a μ-Opioid Receptor Conformational State That Selectively Triggers G Protein Signaling Pathways

[5] Aashish Manglik, et al. Nature. Structure-based discovery of opioid analgesics with reduced side effects

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Keywords: TRV-130, Oliceridine;Olinvo;TRV 130;TRV130 supplier, Opioid Receptor, inhibitors, activators

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