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TRULI

Cat. No. M11472
TRULI Structure
Synonym:

Lats-IN-1

Size Price Availability Quantity
5mg USD 230  USD230 In stock
10mg USD 400  USD400 In stock
25mg USD 630  USD630 In stock
50mg USD 930  USD930 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

TRULI inhibits Lats1 and Lats2 with IC50 of 0.2 nM, inhibits Yap phosphorylation, induces cell proliferation of multiple cell lines and tissues, and promotes the initial stage of proliferation and regeneration of sensory receptors in the inner ear.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 334.39
Formula C18H14N4OS
CAS Number 1424635-83-5
Purity >99%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
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Antide

Sequence:Ac-D2Nal-DCpa-DPal-Ser-Lys(nicotinoyl)-DLys(nicotinoyl)-Leu-Lys(isopropyl)-Pro-DAla-NH2

NE-CARBOXYMETHYL-L-LYSINE

NE-CARBOXYMETHYL-L-LYSINE

  Catalog
Abmole Inhibitor Catalog




Keywords: TRULI, Lats-IN-1 supplier, inhibitors

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