TRULI inhibits Lats1 and Lats2 with IC50 of 0.2 nM, inhibits Yap phosphorylation, induces cell proliferation of multiple cell lines and tissues, and promotes the initial stage of proliferation and regeneration of sensory receptors in the inner ear.
| Molecular Weight | 334.39 |
| Formula | C18H14N4OS |
| CAS Number | 1424635-83-5 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Claire Panosian Dunavan. Am J Trop Med Hyg. Are We Truly Winning the War Against Malnutrition?
[2] Ben L Carty, et al. J Cell Biol. Truly epigenetic: A centromere finds a "neo" home
[4] Josh Loeb. Vet Rec. Should we be truly customer-centric?
[5] Ioanna Comstock, et al. Fertil Steril. Are too many eggs truly too many?
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