TRITC-dextran (70 kDa) is a fluorescent derivative of a dextran fraction with an average molecular weight of approximately 70000. TRITC dextrans are prepared from special dextran fractions by coupling to tetramethylrhodamine B isothiocyanate (mixed isomers). TRITC-dextrans are supplied as a pink powder which is readily soluble in water. TRITC-dextran is mainly used for studying permeability and microcirculation. It can also be used as a molecular size marker, for studies of drug delivery and more.
|Solubility (25°C)||Soluble in water|
|Storage||4°C, dry, sealed|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Haoran Chen, et al. Front Chem. Mouse Strain- and Charge-Dependent Vessel Permeability of Nanoparticles at the Lower Size Limit
 Usmah Kawoos, et al. Front Neurol. N-acetylcysteine Amide Ameliorates Blast-Induced Changes in Blood-Brain Barrier Integrity in Rats
 Ngo Bich Nga Nathalie Tran, et al. Eur J Pharm Biopharm. Gradient-dependent release of the model drug TRITC-dextran from FITC-labeled BSA hydrogel nanocarriers in the hair follicles of porcine ear skin
 Alexa Patzelt, et al. J Control Release. Do nanoparticles have a future in dermal drug delivery?
 Rainelli Koumangoye, et al. Am J Physiol Cell Physiol. Loss of NKCC1 function increases epithelial tight junction permeability by upregulating claudin-2 expression
|Dextran (Mw 150000)
Dextran is a multipurpose branched glucan, which can improve plasma colloid osmotic pressure, increase blood volume, reduce platelet adhesion, inhibit red blood cell aggregation, reduce blood viscosity, reduce peripheral circulation resistance, and unclog microcirculation.
Zeatin is a coconut milk-derived plant hormone and is a common plant cytokinin that is found in the developing or meristematic tissues and organs such as roots, shoot apex, immature organs, and others.
Carbidopa monohydrate is a dopa decarboxylase (DDC) inhibitor, which can be used for the research of Parkinson's disease. Carbidopa monohydrate is also a selective aryl hydrocarbon receptor (AhR) modulator.
|Poly-L-lysine (MW 15000~30000)
Poly-L-lysine (MW 15000~30000)
|Poly-L-lysine (MW 30000~70000)
Poly-L-lysine (MW 30000~70000)
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