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TRITC-dextran (70 kDa)

Cat. No. M22495
TRITC-dextran (70 kDa) Structure

TRITC-dextran 70

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500mg USD 1200  USD1200 In stock
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Biological Activity

TRITC-dextran (70 kDa) is a fluorescent derivative of a dextran fraction with an average molecular weight of approximately 70000. TRITC dextrans are prepared from special dextran fractions by coupling to tetramethylrhodamine B isothiocyanate (mixed isomers). TRITC-dextrans are supplied as a pink powder which is readily soluble in water. TRITC-dextran is mainly used for studying permeability and microcirculation. It can also be used as a molecular size marker, for studies of drug delivery and more.

Chemical Information
Molecular Weight 70000
Solubility (25°C) Soluble in water
Storage 4°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Haoran Chen, et al. Front Chem. Mouse Strain- and Charge-Dependent Vessel Permeability of Nanoparticles at the Lower Size Limit

[2] Usmah Kawoos, et al. Front Neurol. N-acetylcysteine Amide Ameliorates Blast-Induced Changes in Blood-Brain Barrier Integrity in Rats

[3] Ngo Bich Nga Nathalie Tran, et al. Eur J Pharm Biopharm. Gradient-dependent release of the model drug TRITC-dextran from FITC-labeled BSA hydrogel nanocarriers in the hair follicles of porcine ear skin

[4] Alexa Patzelt, et al. J Control Release. Do nanoparticles have a future in dermal drug delivery?

[5] Rainelli Koumangoye, et al. Am J Physiol Cell Physiol. Loss of NKCC1 function increases epithelial tight junction permeability by upregulating claudin-2 expression

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