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Triparanol

Cat. No. M8811

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Triparanol Structure
Synonym:

MER-29

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1mg USD 370  USD370 3-4 Weeks
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Biological Activity

Triparanol (MER-29) is a potent cholesterol biosynthesis inhibitor blocking the 24-dehydrocholesterol reductase (24-DHCR). Triparanol can interfere with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hh signaling. Triparanol can block proliferation and induce apoptosis in multiple human cancer cells including lung, breast, liver, pancreatic, prostate cancer and melanoma cells, and growth inhibition can be rescued by exogenous addition of cholesterol.

Chemical Information
Molecular Weight 438
Formula C27H32NO2Cl
CAS Number 78-41-1
Solubility (25°C) DMSO 45 mg/mL
Storage Powder -20°C
References

[1] Arbace Officioso, et al. Triggering of Erythrocyte Death by Triparanol

[2] Xinyu Bi, et al. Triparanol suppresses human tumor growth in vitro and in vivo

[3] L von Sallmann, et al. Triparanol-induced Cataract in Rats

[4] H J ROBERTS. TRIPARANOL MYXEDEMA

[5] A RAVINA. Triparanol

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Keywords: Triparanol, MER-29 supplier, inhibitors, activators

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