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Trimethyloctadecylammonium bromide

Cat. No. M20482
Trimethyloctadecylammonium bromide Structure
Synonym:

Octadecyltrimethylammonium bromide

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Biological Activity

Trimethyloctadecylammonium bromide is a Dynamin I inhibitor with an IC50 of 1.9 μM and also inhibits Dynamin Ⅱ.

Chemical Information
Molecular Weight 392.50
Formula C21H46BrN
CAS Number 1120-02-1
Solubility (25°C) DMSO 11 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ruqaiyyah Siddiqui, et al. Int Ophthalmol. Antibacterial effects of octadecyl trimethylammonium micelle-clay complex against bacterial eye pathogens: potential as a contact lens disinfectant

[2] Yingxue Xue, et al. Front Pharmacol. Synthesis, Anti-Tumor Activity and Apoptosis-Inducing Effect of Novel Dimeric Keggin-Type Phosphotungstate

[3] Alize Dufour, et al. J Chromatogr A. Chromatographic behavior and characterization of polydisperse surfactants using Ultra-High-Performance Liquid Chromatography hyphenated to High-Resolution Mass Spectrometry

[4] Zezhen Pan, et al. Environ Sci Technol. Cr(VI) Adsorption on Engineered Iron Oxide Nanoparticles: Exploring Complexation Processes and Water Chemistry

[5] Feng Zhou, et al. Sci Rep. Synergetic signal amplification of multi-walled carbon nanotubes-Fe3O4 hybrid and trimethyloctadecylammonium bromide as a highly sensitive detection platform for tetrabromobisphenol A

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Keywords: Trimethyloctadecylammonium bromide, Octadecyltrimethylammonium bromide supplier, Dynamin, inhibitors, activators


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