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Terapidil is an antiplatelet compound that partially acts as a competitive inhibitor of phosphodiesterase inhibitors and platelet-derived growth factor (PDGF) receptors. Tropidil has vasodilation and NO release effect, which may alleviate tissue injury to some extent. Trepatil inhibits raf-1 / extracellular signal-regulated kinase (ERK) by inhibiting platelet-derived growth factor (PDGF) -induced proliferation of vascular smooth muscle cells (VSMC) through cAMP/ protein kinase A (PKA). In addn. Trampidil inhibited the activation of RhoA/ROCK by cAMP/PKA.
| Molecular Weight | 205.26 |
| Formula | C10H15N5 |
| CAS Number | 15421-84-8 |
| Solubility (25°C) | Water ≥ 50 mg/mL DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Yilin Wang, et al. Trapidil determines the fate of RHF rats through inhibition of ER stress
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