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trans-Zeatin

Cat. No. M9432
trans-Zeatin Structure
Size Price Availability Quantity
10mg USD 50  USD50 In stock
100mg USD 150  USD150 In stock
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Quality Control
  • Current batch:
  • Purity >99%, BR
  • COA
  • MSDS
Biological Activity

trans-Zeatin is a plant cytokinin, which plays an important role in cell growth, differentiation, and division. trans-Zeatin (20, 40 or 80 μM) inhibits UV-induced MEK/ERK activation, upregulates AQP3 in a time- and dose-dependent manner, and attenuates UV induced loss of AQP3 in keratinocytes (HaCaT cells).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 219.24
Formula C10H13N5O
CAS Number 1637-39-4
Purity >99%, BR
Solubility DMSO ≥ 20 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: trans-Zeatin supplier, MEK, inhibitors

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