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TOFA

Cat. No. M8819

All AbMole products are for research use only, cannot be used for human consumption.

TOFA Structure
Synonym:

RMI14514; MDL14514

Size Price Availability Quantity
1mg USD 25  USD25 In stock
5mg USD 38  USD38 In stock
10mg USD 65  USD65 In stock
25mg USD 130  USD130 In stock
50mg USD 240  USD240 In stock
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Quality Control & Documentation
Biological Activity

TOFA is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA). TOFA can inhibit the anorectic effect of subcutaneous tamoxifen (TMX) on food intake during refeeding experiments in rats.

Chemical Information
Molecular Weight 324.45
Formula C19H32O4
CAS Number 54857-86-2
Solubility (25°C) DMSO 32 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Andreas Kerschbaumer, et al. Points to consider for the treatment of immune-mediated inflammatory diseases with Janus kinase inhibitors: a systematic literature research

[2] Fang-Fang Zhu, et al. Different effects of acetyl-CoA carboxylase inhibitor TOFA on airway inflammation and airway resistance in a mice model of asthma

[3] Dejiao He, et al. TOFA induces cell cycle arrest and apoptosis in ACHN and 786-O cells through inhibiting PI3K/Akt/mTOR pathway

[4] Shu Li, et al. TOFA suppresses ovarian cancer cell growth in vitro and in vivo

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Keywords: TOFA, RMI14514; MDL14514 supplier, inhibitors, activators

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