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TMX-4116 is a casein kinase 1α (CK1α) degradation agent. tmx-4116 shows a preference for CK1α degradation in MOLT4, Jurkat and MM.1S cells with DC50 less than 200 nM. tmx-4116 can be used in the study of multiple myeloma.
| Molecular Weight | 389.43 |
| Formula | C17H19N5O4S |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Casein Kinase Products |
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SJ3149 is a selective and potent degrader of CK1α protein in vitro and in vivo. |
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CK1α degrader-1 is an orally active CK1α degrader with a DC50 of 0.105 μM. |
| ON 108600
ON 108600 is an inhibitor of CK2 (Casein Kinase2)/TNIK/DYRK1 with IC50 values of 0.016 μm/0.007 μM, 0.028 μM, 0.05 μM/0.005 μM, and 0.005 μM for DYRK1A/DYRKB, DYRK2, CK2α1/CK2α2, and TNIK, respectively. 0.005 μM. It has anti-tumor activity. |
| (R)-DRF053 dihydrochloride
(R)-DRF053 dihydrochloride is a potent inhibitor of casein kinase 1 (CK1), CDK1/cyclin B, and CDK5/p25, with IC50s of 14 nM, 220 nM, and 80 nM, respectively.(R)-DRF053 dihydrochloride prevented the production of CK1-dependent amyloid-β in cellular models. In addition, (R)-DRF053 dihydrochloride prevented the production of CK1-dependent amyloid-β in cell models. |
| Casein kinase 1δ-IN-5
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