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Cat. No. M11517
TMA-DPH Structure
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1mg USD 98  USD98 Out of stock
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Quality Control & Documentation
Biological Activity

Tma-dph contains a cationic trimethylammonium substitute that can be used as a surface anchor locator to improve the localization of the fluorescent probe DPH in the membrane. The maximum excitation/emission wavelength is 355nm/430nm, and it is blue fluorescent and stored at room temperature away from light.

*The compound is unstable in solutions, freshly prepared is recommended

Chemical Information
Molecular Weight 461.62
Formula C28H31NO3S
CAS Number 115534-33-3
Solubility (25°C) N/A
Storage -20°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Antnio M T M do Canto, et al. Biochim Biophys Acta. Diphenylhexatriene membrane probes DPH and TMA-DPH: A comparative molecular dynamics simulation study

[2] Brad Chazotte. Cold Spring Harb Protoc. Labeling the plasma membrane with TMA-DPH

[3] C Saldanha, et al. J Membr Biol. Fluorescent probes DPH, TMA-DPH and C17-HC induce erythrocyte exovesiculation

[4] G Ferretti, et al. Membr Biochem. Properties of a phosphatidylcholine derivative of diphenyl hexatriene (DPH-PC) in lymphocyte membranes. A comparison with DPH and the cationic derivative TMA-DPH using static and dynamic fluorescence

[5] A Benedetti, et al. J Gastroenterol Hepatol. Plasma membrane fluidity in isolated rat hepatocytes: comparative study using DPH and TMA-DPH as fluorescent probes

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Keywords: TMA-DPH supplier, Fluorescent Dye, inhibitors, activators

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