Thioflavine S is a fluorescent histochemical marker of dense core senile plaques.
|Solubility (25°C)||Water ≥ 50 mg/mL|
|Storage||2-8°C, protect from light|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Shawn M Barton, et al. Molecules. Inhalable Thioflavin S for the Detection of Amyloid Beta Deposits in the Retina
 Xing Ze Wang, et al. Analyst. Driving force to detect Alzheimer's disease biomarkers: application of a thioflavine [email protected] ratiometric fluorescent sensor for smart detection of presenilin 1, amyloid β-protein and acetylcholine
 Matthew Biancalana, et al. Biochim Biophys Acta. Molecular mechanism of Thioflavin-T binding to amyloid fibrils
 D Larry Sparks. J Mol Neurosci. Cholesterol, copper, and accumulation of thioflavine S-reactive Alzheimer's-like amyloid beta in rabbit brain
 R Guntern, et al. Experientia. An improved thioflavine S method for staining neurofibrillary tangles and senile plaques in Alzheimer's disease
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