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Thioflavine S

Cat. No. M13803
Thioflavine S Structure
Synonym:

Thioflavin S; Direct Yellow 7

Size Price Availability Quantity
100mg USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Thioflavine S is a fluorescent histochemical marker of dense core senile plaques.

Chemical Information
CAS Number 1326-12-1
Solubility (25°C) Water ≥ 50 mg/mL
Storage 2-8°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shawn M Barton, et al. Molecules. Inhalable Thioflavin S for the Detection of Amyloid Beta Deposits in the Retina

[2] Xing Ze Wang, et al. Analyst. Driving force to detect Alzheimer's disease biomarkers: application of a thioflavine T@Er-MOF ratiometric fluorescent sensor for smart detection of presenilin 1, amyloid β-protein and acetylcholine

[3] Matthew Biancalana, et al. Biochim Biophys Acta. Molecular mechanism of Thioflavin-T binding to amyloid fibrils

[4] D Larry Sparks. J Mol Neurosci. Cholesterol, copper, and accumulation of thioflavine S-reactive Alzheimer's-like amyloid beta in rabbit brain

[5] R Guntern, et al. Experientia. An improved thioflavine S method for staining neurofibrillary tangles and senile plaques in Alzheimer's disease

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Keywords: Thioflavine S, Thioflavin S; Direct Yellow 7 supplier, Fluorescent Dye, inhibitors, activators


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