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Thamnosmonin

Cat. No. M16297
Thamnosmonin Structure
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Biological Activity

Thamnosmonin

Chemical Information
CAS Number 60094-90-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ulrich Membe Femoe, et al. Evid Based Complement Alternat Med. In Vitro Assessment of the Cercaricidal Activity of Sida acuta Burm. F. and Sida rhombifolia Linn. (Malvaceae) Hydroethanolic Extracts, Cytotoxicity, and Phytochemical Studies

[2] Blaise Cedric Kamdoum, et al. Nat Prod Res. Chemical constituents of two Cameroonian medicinal plants: Sida rhombifolia L. and Sida acuta Burm. f. (Malvaceae) and their antiplasmodial activity

[3] Sheng Huang, et al. Zhong Yao Cai. [Study on the chemical constituents from ethyl acetate extract of Micromelum falcatum]

[4] Wei-Lie Xiao, et al. Arch Pharm Res. Two new coumarin glucosides from the roots of Angelica apaensis and their anti-platelet aggregation activity

[5] C Bayet, et al. Phytother Res. Modulation of P-glycoprotein activity by acridones and coumarins from Citrus sinensis

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