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TGFβ1-IN-1 is a potent, orally active TGF-β1 inhibitor. TGFβ1-IN-1 inhibits the upregulation of TGF-β1-induced fibrosis markers (α-SMA and fibronectin). TGFβ1-IN-1 (0-20 μM, 72 h) inhibits the proliferation of TGF-β1 (5 ng/mL)-treated LX-2 cells and inhibits LO2 cell viability with an IC50 of 105 μM.
TGFβ1-IN-1 (15 or 30 mg/kg, p.o., daily, 3weeks) prevents CCl4-induced liver injury and fibrosis, inhibits the activation of hepatic stellate cell (HSC) and epithelial-mesenchymal transition (EMT), and improves the immune microenvironment of CCl4-induced liver fibrosis as well as CCl4-induced systemic toxicity in C57BL/6J mice.
| Molecular Weight | 364.44 |
| Formula | C22H24N2O3 |
| CAS Number | 2348795-14-0 |
| Solubility (25°C) | DMSO 75 mg/mL |
| Storage | 4°C, protect from light, dry, sealed |
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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