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Tetraphenylporphyrin

Cat. No. M10204
Tetraphenylporphyrin Structure
Synonym:

TPP; Tetraphenylporphine

Size Price Availability Quantity
500mg USD 50  USD50 In stock
1g USD 75  USD75 In stock
5g USD 200  USD200 In stock
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Quality Control & Documentation
Biological Activity

Tetraphenylporphyrin, abbreviated TPP or H2TPP, is a synthetic heterocyclic compound that resembles naturally occurring porphyrins. Porphyrins are dyes and cofactors found in hemoglobin and cytochromes and are related to chlorophyll and vitamin B12.

Chemical Information
Molecular Weight 614.74
Formula C44H30N4
CAS Number 917-23-7
Solubility (25°C) Soluble in chloroform
Soluble in benzene
Storage 2-8°C, dry, sealed, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] ZHAO Dan, et al. DETERMINATION OF ZINC AND CADMIUM IONS USING TETRAPHENYLPORPHYRIN (TPP) SPECTROPHOTOMETRY

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