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Terpin hydrate

Cat. No. M6003
Terpin hydrate Structure
Synonym:

Terpin monohydrate; cis-Terpin hydrate

Size Price Availability Quantity
100mg USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Terpin hydrate is an expectorant, commonly used to loosen mucus in patients presenting with acute or chronic bronchitis, and related conditions.

Chemical Information
Molecular Weight 190.28
Formula C10H20O2.H2O
CAS Number 2451-01-6
Solubility (25°C) 38 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Baum RH, et al. J Bacteriol. cis-terpin hydrate metabolism by a Brevibacterium: patterns of enzyme induction, and accumulation of -terpineol in growth.

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Keywords: Terpin hydrate, Terpin monohydrate; cis-Terpin hydrate supplier, inhibitors, activators


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