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Tephrosin

Cat. No. M14141
Tephrosin Structure
Synonym:

Deguelinol I; Hydroxydeguelin

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Tephrosin is a natural rotenoid which has potent antitumor activities. Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 410.42
Formula
CAS Number 76-80-2
Purity >99%
Solubility
Storage 2-8°C, protect from light
References

[1] Sina Darzi, et al. Improvement of cytotoxicity of mitoxantrone and daunorubicin by candidone, tephrosin, and bavachinin

[2] Jie Du, et al. Tephrosin induces apoptosis of human pancreatic cancer cells through the generation of reactive oxygen species

[3] Sina Darzi, et al. Enhancing the Therapeutic Efficacy of Daunorubicin and Mitoxantrone with Bavachinin, Candidone, and Tephrosin

[4] David A Russell, et al. Stereocontrolled semi-syntheses of deguelin and tephrosin

[5] Jing Li, et al. Tephrosin-induced autophagic cell death in A549 non-small cell lung cancer cells

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Keywords: Tephrosin, Deguelinol I; Hydroxydeguelin supplier, EGFR/HER2, inhibitors

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