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TC-S 7005

Cat. No. M9307
TC-S 7005 Structure
Synonym:

ABM-9921

Size Price Availability
10mg USD 628  USD628 1-2 Weeks
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Quality Control & Documentation
Biological Activity

TC-S 7005 is a potent and selective polo-like kinase 2 (PLK2) inhibitor (IC50 = 4 nM). TC-S 7005 shows selectivity for PLK2 over PLK3 and PLK1 (IC50 values are 24 and 214 nM respectively). TC-S 7005 induces mitotic arrest and cell death in HCT 116 colorectal cells.

Chemical Information
Molecular Weight 359.38
Formula C21H17N3O3
CAS Number 1082739-92-1
Solubility (25°C) DMSO: ≥ 25 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hanan EJ, et al. Bioorg Med Chem Lett. Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors.

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  Catalog
Abmole Inhibitor Catalog




Keywords: TC-S 7005, ABM-9921 supplier, PLK, inhibitors, activators


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