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PLK Polo-like kinase

Inhibitors

Cat.No.  Name Information
M1672 BI 2536 BI 2536 is a novel, highly selective, potent dual PLK1 and BRD4 inhibitor with IC50s of 0.83 and 25 nM, respectively.
M9307 TC-S 7005 TC-S 7005 is a potent and selective polo-like kinase 2 (PLK2) inhibitor (IC50 = 4 nM).
M9250 HMN-176 HMN-176 inhibits mitosis, interfering with polo-like kinase-1 (plk1), without significant effect on tubulin polymerization.
M8519 Mps1-IN-2 Mps1-IN-2 is a potent and selective inhibitor of Mps1 kinase.
M7559 ON1231320 ON1231320, also known as GBO-006, is a Polo-like kinase 2 (PLK2) inhibitor. In vitro testing revealed that ON1231320 is a selective inhibitor of PLK2 with no inhibitory activity against PLK1, PLK3 and PLK4.
M7271 SBE13 hydrochloride SBE13 hydrochloride is a potent and selective PLK1 inhibitor.
M3293 HMN-214 HMN-214 is a procompound of HMN-176, which alters the cellular spatial orientation of Plk1.
M3198 TAK-960 TAK-960 is a novel, potent and selective Plk1 inhibitor with IC50 of 8 nM.
M2983 Ro3280 RO3280 is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM.
M2860 MLN0905 MLN0905 is a potent inhibitor of PLK1 with IC50 of 2 nM.
M2741 GW843682X GW 843682X is a PLK inhibitor for PLK1 and PLK3 with IC50 of 2.2 nM and 9.1 nM, respectively.
M2211 Rigosertib sodium Rigosertib sodium is a dual non-ATP inhibitor of polo-like kinase 1 (Plk1) and phosphoinositide 3-kinase pathways (PI3K).
M1719 GSK461364 GSK461364 is a potent and selective small molecule inhibitor of Polo-like kinase 1 (PLK1) with a Ki of 2.2 nM.
M1678 BI 6727 BI 6727 (Volasertib) is a small highly potent Polo-like kinase inhibitor (Plk1) with an IC50 of 0 .87 nM.
M1672 BI 2536 BI 2536 is a novel, highly selective, potent dual PLK1 and BRD4 inhibitor with IC50s of 0.83 and 25 nM, respectively.



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