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Tanshinone IIA suppresses angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2. Tanshinone IIA protects rat myocardium-derived H9C2 cells against apoptosis. Treatment of H9C2 cells with Tanshinone IIA inhibits angiotensin II-induced apoptosis by downregulating the expression of PTEN (phosphatase and tensin homolog), a tumor suppressor that plays a critical role in apoptosis.
*The compound is unstable in solutions, freshly prepared is recommended.
| Molecular Weight | 294.34 |
| Formula | C19H18O3 |
| CAS Number | 568-72-9 |
| Solubility (25°C) | Ethanol 5 mg/mL DMSO 3 mg/mL |
| Storage | 2-8°C, dry, sealed |
| Related VEGFR/PDGFR Products |
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