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Talacotuzumab

Cat. No. M24827

All AbMole products are for research use only, cannot be used for human consumption.

Talacotuzumab Structure
Synonym:

JNJ 56022473; CSL 362

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Quality Control & Documentation
Biological Activity

Talacotuzumab (JNJ 56022473; CSL 362) is an IgG1-type fully humanized, CD123-neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has KDs of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab has mutated the Fc region to increase affinity for CD16 (FcγRIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models.

Chemical Information
CAS Number 1826831-79-1
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] John Devin Peipert, et al. J Geriatr Oncol. Patient-reported outcomes predict overall survival in older patients with acute myeloid leukemia

[2] Pau Montesinos, et al. Leukemia. Safety and efficacy of talacotuzumab plus decitabine or decitabine alone in patients with acute myeloid leukemia not eligible for chemotherapy: results from a multicenter, randomized, phase 2/3 study

[3] Anne Sophie Kubasch, et al. Leukemia. Single agent talacotuzumab demonstrates limited efficacy but considerable toxicity in elderly high-risk MDS or AML patients failing hypomethylating agents

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Keywords: Talacotuzumab, JNJ 56022473; CSL 362 supplier, IL Receptor/Related, inhibitors, activators

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