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SY-1365

Cat. No. M9489
SY-1365 Structure
Synonym:

Mevociclib

Size Price Availability
5mg USD 350  USD350 4-7 Days
10mg USD 650  USD650 4-7 Days
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Quality Control & Documentation
Biological Activity

SY-1365 (Mevociclib) is a selective covalent CDK7 inhibitor. SY-1365 inhibited cell growth of many different cancer types at nanomolar concentrations. SY-1365 treatment decreased MCL1 protein levels, and cancer cells with low BCL-XL expression were found to be more sensitive to SY-1365. SY-1365 demonstrated substantial anti-tumor effects in multiple AML xenograft models as a single agent. SY-1365-induced growth inhibition was enhanced in combination with the BCL2 inhibitor venetoclax.

Chemical Information
Molecular Weight 587.12
Formula C31H35ClN8O2
CAS Number 1816989-16-8
Solubility (25°C) DMSO 10mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hu S, et al. Cancer Res. Discovery and Characterization of SY-1365, a Selective, Covalent Inhibitor of CDK7.

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  Catalog
Abmole Inhibitor Catalog




Keywords: SY-1365, Mevociclib supplier, CDK, inhibitors, activators


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