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Surfen dihydrochloride

Cat. No. M30269

All AbMole products are for research use only, cannot be used for human consumption.

Surfen dihydrochloride Structure
Synonym:

Aminoquincarbamide dihydrochloride

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Quality Control & Documentation
Biological Activity

Surfen dihydrochloride is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection.

Chemical Information
Molecular Weight 445.34
Formula C21H22Cl2N6O
CAS Number 5424-37-3
Form Solid
Solubility (25°C) Water 8 mg/mL (Need ultrasonic and warming)
Storage 4°C, protect from light, dry, sealed
References

[1] Meghan T Logun, et al. FASEB J. Surfen-mediated blockade of extratumoral chondroitin sulfate glycosaminoglycans inhibits glioblastoma invasion

[2] Seyedeh Maryam Alavi Naini, et al. Transl Neurodegener. Surfen and oxalyl surfen decrease tau hyperphosphorylation and mitigate neuron deficits in vivo in a zebrafish model of tauopathy

[3] Jordan R Warford, et al. Acta Neuropathol Commun. Surfen, a proteoglycan binding agent, reduces inflammation but inhibits remyelination in murine models of Multiple Sclerosis

[4] Yen-Ting Wang, et al. ACS Sens. Surfen-Assembled Graphene Oxide for Fluorescence Turn-On Detection of Sulfated Glycosaminoglycans in Biological Matrix

[5] Jordan Warford, et al. Biochem Biophys Res Commun. Murine T cell activation is regulated by surfen (bis-2-methyl-4-amino-quinolyl-6-carbamide)

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Keywords: Surfen dihydrochloride, Aminoquincarbamide dihydrochloride supplier, FGFR, inhibitors, activators

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