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Sunvozertinib

Cat. No. M11447

All AbMole products are for research use only, cannot be used for human consumption.

Sunvozertinib Structure
Synonym:

DZD9008

Size Price Availability Quantity
1mg USD 80  USD80 In stock
5mg USD 180  USD180 In stock
10mg USD 290  USD290 In stock
25mg USD 540  USD540 In stock
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Quality Control & Documentation
Biological Activity

Sunvozertinib (DZD9008) is an effective inhibitor of ErbBs (EGFR, Her2, especially mutants) and BTK. Sunvozertinib showed EGFR exon 20 NPH insertion, EGFR exon 20 ASV insertion, EGFR L858R and T790M mutations, and IC50 of Her2 exon 20 YVMA and EGFR WT A431 They are 20.4, 20.4, 1.1, 7.5 and 80.4 nM respectively (please refer to patent WO2019149164A1, Example 52 for details).

Chemical Information
Molecular Weight 584.08
Formula C29H35ClFN7O3
CAS Number 2370013-12-8
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Mengzhao Wang, et al. Cancer Discov. Sunvozertinib, a selective EGFR inhibitor for previously treated non-small cell lung cancer with EGFR exon 20 insertion mutations

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Keywords: Sunvozertinib, DZD9008 supplier, EGFR/HER2, inhibitors, activators

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