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Sulfatase (from Helix pomatia) facilitates the synthesis of thiohydroximates. It causes the hydrolysis of β-naphthyl sulfate much faster than a-naphthyl sulfate and possesses regiospecificity in the hydrolysis of ortho and para substituted phenyl sulfates.
Sulfonation and sulfation are catalyzed by various sulfotransferases. In turn, desulfonation and desulfation occur via the action of sulfatase. Sulfonation and sulfation are important processes in the metabolism of compounds such as hormones, neurotransmitters, and drugs.
Helix pomatia sulfatase can be used for deconjugation studies of various compounds, including:
Environmental contaminants, such as bisphenol A
Hirudin
Vitamin E metabolites
β-adrenoreceptor agonists
Lignans from carob germ and carob seed
Unit definition: One unit will hydrolyze 1.0 µmole of p-nitrocatechol sulfate per hour at pH 5.0 at 37 °C, in a 30-minute assay.
Sulfatase activity: ≥10,000 units/g solid
Enzyme Commission (EC) Number: 3.1.6.1
Synonyms: Aryl-sulfatase, Aryl-sulfate sulfohydrolase, Phenolsulfatase
| CAS Number | 9016-17-5 |
| Form | Powder |
| Solubility (25°C) | Preparation of solutions of this sulfatase product at 100 units/mL in 200 mM sodium acetate buffer with 20 mM saccharic acid 1,4-lactone. |
| Storage | -20°C |
[5] Frederick C Kauffman. Drug Metab Rev. Sulfonation in pharmacology and toxicology
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