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SU5204

Cat. No. M20740
SU5204 Structure
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Quality Control & Documentation
Biological Activity

SU5204 is a tyrosine kinase inhibitor with IC50 of 4 μM and 51.5 μM for FLK-1 (VEGFR-2) and HER2, respectively.

Chemical Information
Molecular Weight 265.31
Formula C17H15NO2
CAS Number 186611-11-0
Solubility (25°C) DMSO 53 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Casey C Raymond, et al. Acta Crystallogr E Crystallogr Commun. Crystal structure of 1,4,5,6,7,8,9,10,11,12,13-undeca-hydro-cyclo-dodeca[c]pyrazol-3-ol

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Keywords: SU5204 supplier, VEGFR/PDGFR, inhibitors, activators


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