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SU 5214

Cat. No. M9283
SU 5214 Structure
Synonym:

SU5214

Size Price Availability Quantity
10mg USD 480  USD480 In stock
25mg USD 1160  USD1160 In stock
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Quality Control & Documentation
Biological Activity

SU 5214 is a modulator of tyrosine kinase signal transduction, with IC50 values of 14.8 µM (FLK-1) and 36.7 µM (EGFR), respectively.

Chemical Information
Molecular Weight 251.28
Formula C16H13NO2
CAS Number 186611-04-1
Solubility (25°C) DMSO 10 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yiqing Tan, et al. Tumor suppressor DRD2 facilitates M1 macrophages and restricts NF-κB signaling to trigger pyroptosis in breast cancer

[2] Xiaodong Wang, et al. Predicting gastric cancer outcome from resected lymph node histopathology images using deep learning

[3] Hye-Kyung Jung, et al. 2019 Seoul Consensus on Esophageal Achalasia Guidelines

[4] Soyeun Kim, et al. Novel Emerging Therapies for Erectile Dysfunction

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