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SU 5201

Cat. No. M20712
SU 5201 Structure
Synonym:

NSC 247030

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Biological Activity

SU 5201 (NSC 247030) is an interleukin-2 (IL-2) inhibitor.

Chemical Information
Molecular Weight 290.14
Formula C15H9Cl2NO
CAS Number 114727-43-4
Solubility (25°C) DMSO 58 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xiangfeng Lu, et al. Eur Heart J. A polygenic risk score improves risk stratification of coronary artery disease: a large-scale prospective Chinese cohort study

[2] Ansam Sinjab, et al. Cancer Discov. Resolving the Spatial and Cellular Architecture of Lung Adenocarcinoma by Multiregion Single-Cell Sequencing

[3] Joachim K Krauss, et al. Nat Rev Neurol. Technology of deep brain stimulation: current status and future directions

[4] Changjun Yin, et al. Nat Med. ApoE attenuates unresolvable inflammation by complex formation with activated C1q

[5] Andres M Lozano, et al. Nat Rev Neurol. Deep brain stimulation: current challenges and future directions

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  Catalog
Abmole Inhibitor Catalog




Keywords: SU 5201, NSC 247030 supplier, IL Receptor/Related, inhibitors, activators


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