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Streptavidin

Cat. No. M15062
Streptavidin Structure
Size Price Availability Quantity
1mg USD 48  USD48 In stock
5mg USD 150  USD150 In stock
25mg USD 300  USD300 In stock
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Quality Control & Documentation
  • Purity: ≥14 units/mg protein
  • COA
  • MSDS
Biological Activity

Streptavidin is an isotype tetramer of about 60 kDa. Streptavidin binds four biotin molecules with high affinity. Streptavidin is immunosuppressive.

Chemical Information
Molecular Weight 378.71228
Formula C14H17BrClNO2S
CAS Number 9013-20-1
Solubility (25°C) Water:1 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] P H Erik Hamming, et al. ACS Appl Mater Interfaces. Streptavidin Coverage on Biotinylated Surfaces

[2] Bintian Zhang, et al. J Am Chem Soc. Probing Bioelectronic Connections Using Streptavidin Molecules with Modified Valency

[3] Mona Sarter, et al. J Phys Chem B. Strong Adverse Contribution of Conformational Dynamics to Streptavidin-Biotin Binding

[4] Kok Hong Lim, et al. Biotechnol Bioeng. Stable, high-affinity streptavidin monomer for protein labeling and monovalent biotin detection

[5] P S Stayton, et al. Biomol Eng. Streptavidin-biotin binding energetics

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