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SR17018

Cat. No. M10584
SR17018 Structure
Synonym:

SR-17018

Size Price Availability
5mg USD 250  USD250 4-7 Days
10mg USD 350  USD350 4-7 Days
25mg USD 700  USD700 4-7 Days
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

SR17018 is an mu-opioid-receptor (MOR) agonist with an EC50 of 97 nM. SR17018 promotes signaling through G proteins or βarrestin2.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 410.72
Formula C19H18Cl3N3O
CAS Number 2134602-45-0
Purity >98%
Solubility DMSO 10 mg/mL
Storage at -20°C
References

[1] Cullen L Schmid, et al. Cell. Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics

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Keywords: SR17018, SR-17018 supplier, Opioid Receptor, inhibitors

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