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SPL-707 is an orally active, selective signal peptide peptidase-like 2a (SPPL2a) inhibitor with an IC50 of 77 nM for hSPPL2a. SPL-707 inhibits γ-secretase (IC50=6.1 μM) and SPP (IC50=3.7 μM). SPL-707 has the potential for autoimmune diseases research by targeting B cells and dendritic cells.
| Molecular Weight | 505.54 |
| Formula | C27H28FN5O4 |
| CAS Number | 2195361-33-0 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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| RE(EDANS)EVNLDAEFK(DABCYL)R
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| β-Secretase inhibitor
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| Mca-SEVNLDAEFK(Dnp)
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| BACE1-IN-10
BACE1-IN-10 is a potent BACE1 Inhibitor. |
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