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Spiraeoside

Cat. No. M40778
Spiraeoside Structure
Size Price Availability Quantity
5mg USD 460  USD460 In stock
10mg USD 660  USD660 In stock
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Biological Activity

Spiraeoside is an orally bioavailable natural flavonoid that inhibits the production of reactive oxygen species (ROS) and malondialdehyde, and possesses antioxidant activity, anti-inflammatory as well as anti-tumor activity.

Chemical Information
Molecular Weight 464.38
Formula C21H20O12
CAS Number 20229-56-5
Form Solid
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Lokman Durmaz et al. Saudi Pharm J. Potential antioxidant, anticholinergic, antidiabetic and antiglaucoma activities and molecular docking of spiraeoside as a secondary metabolite of onion ( Allium cepa)

[2] Arti Nile et al. Food Chem Toxicol. Spiraeoside extracted from red onion skin ameliorates apoptosis and exerts potent antitumor, antioxidant and enzyme inhibitory effects

[3] Hongyang Liu et al. J Biochem Mol Toxicol. Spiraeoside protects human cardiomyocytes against high glucose-induced injury, oxidative stress, and apoptosis by activation of PI3K/Akt/Nrf2 pathway

[4] Keshab Kumar Karna et al. BMC Complement Altern Med. The ameliorative effect of monotropein, astragalin, and spiraeoside on oxidative stress, endoplasmic reticulum stress, and mitochondrial signaling pathway in varicocelized rats

[5] Jung Kuk Kim et al. Biochem Cell Biol. Spiraeoside inhibits mast cells activation and IgE-mediated allergic responses by suppressing phospholipase C-γ-mediated signaling

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Keywords: Spiraeoside supplier, inhibitors, activators

 
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