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SP-13786 (UAMC-1110) is a novel potent and selective inhibitor of fibroblast activation protein (fap), displaying low nanomolar inhibitory potency and high selectivity against the related dipeptidyl peptidases (dpps) dppiv, dpp9, dppii, and prolyl oligopeptidase (prep). Pharmacokinetic evaluation in mice of SP-13786 demonstrates high oral bioavailability, plasma half-life, and the potential to selectively and completely inhibit FAP in vivo.
| Molecular Weight | 344.32 |
| Formula | C17H14F2N4O2 |
| CAS Number | 1448440-52-5 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related FAP Products |
|---|
| OncoFAP
OncoFAP is an ultra-high-affinity ligand of fibroblast activation protein (FAP) for targeting applications with pan-tumoral potential. |
| ARI-3099
ARI-3099 is potent and selective inhibitor of FAP with a Ki value of 9 nM. |
| 3BP-3940
3BP-3940 is a highly potent fibroblast activation protein (FAP)-targeting peptide for theranostics. |
| NH2-UAMC1110 TFA
NH2-UAMC1110 TFA is a UAMC1110 derivative that can be used in the synthesis of FAPI-QS. |
| FAP-IN-1
FAP-IN-1 is a fibroblast activation protein (FAP) inhibitor with an IC50 value of 3.3 nM. |
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Products are for research use only. Not for human use. We do not sell to patients.
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