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SM16

Cat. No. M9683
SM16 Structure
Synonym:

SM-16

Size Price Availability
10mg USD 211  USD211 4-7 Days
25mg USD 442  USD442 4-7 Days
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

SM16 is a ALK5/ALK4 kinase inhibitor with Kis of 10 and 1.5 nM, respectively. SM16 penetrates tumor cells in vivo, suppressing tumor phosphorylated Smad2/3 levels for at least 3 h following treatment of tumor-bearing mice with a single i.p. bolus of 20 mg/kg SM16.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 430.5
Formula C25H26N4O3
CAS Number 614749-78-9
Purity >99%
Solubility DMSO ≥ 55 mg/mL
Storage at -20°C
References

[1] Kristin V T Engebretsen, et al. J Mol Cell Cardiol. Attenuated development of cardiac fibrosis in left ventricular pressure overload by SM16, an orally active inhibitor of ALK5

[2] Kai Fu, et al. Arterioscler Thromb Vasc Biol. SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model

[3] Eiji Suzuki, et al. Cancer Res. A novel small-molecule inhibitor of transforming growth factor beta type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SM16, SM-16 supplier, TGF-beta/Smad, inhibitors

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